When a mysterious illness overcomes the members of an up and coming rock band, Hank and Divya have to work together to find the cause; but Hank struggles with trusting Divya after her near fatal prescription error. Hank diagnoses Jack with Lupus. Evan has a unique reaction to kissing bugs.

Jack dumps Hank as his doctor and blows off his medical treatment, Hank helps a Shakespearean actor with stomach pains, Divya uses Dr. Van Dyke to impress her ex, and Paige contemplates an opportunity to go away to England for eight weeks.