The sixth season begins with the reinvestigation of a college-football star's murder in 1973 on the eve of a championship game. The unsolved case is reopened when new evidence suggests he was killed earlier than previously assumed. The probe also reveals the victim may have been involved with steroids.

Will and Kat travel to Mississippi to investigate the 1964 death of a Philadelphia woman who was secretly involved in helping bring supplies to the state's Freedom Schools, which educated black children. The victim's body was discovered in Pennsylvania. She was thought to have been involved in a hit-and-run accident, but new evidence, including a threatening letter, points to murder.