Donna's show-off and bossy sister, Janet, and her unruly children come to town to celebrate Thanksgiving with the Browns. Cleveland, still bruised by their past, wants nothing to do with her this Thanksgiving and attempts to drive her out.

Donna, frustrated by her husband's laziness on the weekends, nags Cleveland to help her around the house and to do something more with his life. To prove to Donna he can be as charitable as her, Cleveland recruits his buddies from Quahog and Stoolbend to participate in the First Annual Charity Beer Walk.