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After a teenage girl is murdered in a mental institution, Megan and Tommy interview a seemingly sane young patient who claims that she saw the killer and that she was the actual target, not the victim.
A fund manager on trial for defrauding a billion dollars is kidnapped as he is leaving court, despite being surrounded by security, and during the escape, a protester is killed by the getaway vehicle. Later, video surfaces of the captive being murdered, but there are questions about whether he is really dead.
A plane crashes in Philadelphia after a passenger opens fire, and the entire team pitch in to work the disaster. With the city's main power grid affected by the crash, Megan must conduct autopsies in between blackouts, and during one of them, a body goes missing. Meanwhile, Tommy and Adam get in a serious car accident.
In the wake of Inspector Peter Dunlop's death, Megan returns to work to find her new partner is an old flame. Will her history with Detective Tommy Sullivan make working side by side impossible? Their search for justice becomes even more personal when a serial killer takes Megan's daughter, Lacey, hostage.