Detectives Goren and Eames stumble upon an American tragedy when they trace the slaying of a jewelry thief whose mysterious young female partner is being manipulated by Nicole Wallace -- Goren's murderous and chameleon-like adversary from his past. As the detective carefully interviews his lethal but elusive nemesis, Goren discovers a chilling trail of betrayed victims that exceeds his worst memories as a New York cop.

When the body of several murdered homeless men are found sold to medical labs, Detectives Goren and Eames descend into abandoned subway tunnels - where they encounter its tormented inhabitants - until they discover all of the victims were newly registered for credit cards that were maxed out after their deaths. As they probe further, the investigators find a link to a suspicious auto parts salesman and his addled middle-aged girlfriend.