When Eric and Annie discover that Matt has a secret girlfriend named Renee, they are shocked to see that she's pregnant; with Matt insisting he's not the father. Both Matt and Renee are surprised at Eric's willingness to help her out once she delivers. Mary discovers Lucy has a crush on a classmate and makes fun of her for it. Eric starts losing his shoes and turns to Ruthie for help in finding them. Annie confides in Matt that her mother is sick with leukemia.

Following her mother's funeral, Annie's sunny demeanor turns to sadness, particularly after her father abruptly leaves to go back home to Arizona. Eric tries to counsel a young couple whose marital problems escalate during the post-funeral reception at the Camden home. Matt helps with the delivery of Renee's baby and after Mary breaks up with Jeff, she discovers she was better off with him. Lastly, Simon tries to find the exact location of heaven.