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The Camden family's traditional Thanksgiving is jeopardized when the children want to spend the holiday away from home and Eric's sister reveals a tragic secret.
Simon rightly fears he'll catch roommate Ruthie's chicken-pox, but his enterprising hygienic measures fail to prevent contagion from her or happy's flees. When a robber carjacks them both, Annie seems calm and hands their valuables, so Matt feels 'unmanly' and guilty. However when it comes to an identification line-up, Annie breaks down, only sneakily. Jimmy Moon stands against Lucy in the school elections, then turns to her parents for help. The organist has bizarre periods of excellence and disharmony.
The Camdens become suspicious when Matt's new girlfriend, Tia, wants to spend more time with the family rather than being alone with Matt. Lucy enlists the help of Matt to overcome her clumsiness in order to try out for the cheerleading squad. Annie yearns for more romance in her marriage with Eric as she has become bored with the every-day routines. Simon tries to make himself invisible and tries to convince the whole family that he can be invisible.