An extremely nervous Simon comes home to Glenoak to await the results of his STD test from the clinic. Eric counsels a woman who is caring for her two daughters with sickle cell anemia and whose absentee father is hoping to take them back with him to Memphis, Tennessee for treatment at St. Jude Children's Research Hospital. Meanwhile, Ruthie's ex-boyfriend Peter and his parents Paris and Vic pay a surprise visit to the Camden family, which creates problems for Ruthie and her current boyfriend, Vincent. A pregnant Paris and Vic decide to get married and ask Eric to be the minister to wed them. Also, Lucy and Kevin disagree over who should care for Savannah when Lucy returns to work. Lastly, Martin misses an important call from his father in Iraq while sneaking out of the house to be with his girlfriend. Martin begins to have second thoughts on their relationship.

When Simon and his new girlfriend Rose, make an unexpected visit to Glenoak to meet their respective parents, Annie begins to suspect their relationship might be on a fast track. She lets them know they are not allowed to sleep in the same room together in the house as they spend the night. Rose puts up a fight with both Annie and Simon over the sleeping arrangements, but eventually take will. Meanwhile, Eric hides the news of Mary's divorce, worried that it will most certainly break Annie's heart. Also, Martin becomes the third wheel again in Ruthie's and Vincent's relationship as Ruthie thinks Martin is jealous of their relationship despite the fact that Vincent wants Martin to convince Ruthie to dump him. The adoption process for George and his wife over the Davis children becomes more complicated when their biological mother fights for the adoption process to not happen. Lastly, Martin's father, Bill returns from Iraq to greet his son.