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When Chet Collins, who's young son went missing 6 years ago, also disappears himself, the team discovers that Chet found a break in the case and become concerned that the desperate father has taken matters into his own hands.
The team is called in to locate a pregnant woman who has absconded from hospital in a desperate bid to escape her violent husband, but the investigation becomes doubly urgent by the revelation that she is suffering from a potentially fatal illness.
The team investigates the disappearance of Linda Schmidt, a flight attendant who goes missing after leaving her apartment, supposedly heading to the airport to catch a late flight. Evidence found in her abandoned car suggests she may have fallen victim to a serial killer after meeting a man through an internet dating service.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.