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Jack and the team are called in to find a woman who appears to have been kidnapped by a car thief, but as they interview witnesses they begin to realize the case is more sinister than a random abduction.
The team searches for a boy who has vanished en route to his 11th birthday celebration and was last seen getting on a subway train. By the time the police get involved 16 hours later, a successful recovery starts to look unlikely.
The team is tasked with finding an aspiring model who changes her appearance regularly and has been missing for over a week without anybody noticing, while Jack is haunted by an old case he was unable to solve.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.