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Jack and the team search for Dante Jones, a boxer who vanished just before a much-anticipated fight, and soon begin to suspect his disappearance is a publicity stunt - until his unscrupulous younger brother also goes missing.
A well-liked teacher who is eager to change the world disappears after teaching late at the high school where he works. As the team investigates, they uncover contradictory information about his background - including evidence that he might have been supplementing his income by selling drugs, despite being wealthy to begin with.
When his unconventional methods result in the case against a child molester being thrown out of court, Jack finds himself at the center of an investigation by the Office of Professional Responsibility into how missing persons cases have been handled.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.