A DJ and lawyer undergoes vital surgery for a heart aneurysm, and a mother-of-two is terrified that a returning sarcoma in her pelvis will stop her from raising her children. A carpenter arrives in the emergency room with a dangerously low pacemaker battery.

A leading melanoma pathologist is diagnosed with a deadly brain tumour, so becomes a human guinea pig and trials his untested treatment regimen on himself. A patient receives a long-awaited, life-changing liver transplant, and in the emergency room, a rock-climbing mishap leaves a woman with a badly broken ankle.