Esteban brings Clara to their new home in the capital, "the big house on the corner." After their daughter Blanca is born, the family-including Esteban's sister, Férula-travels to Las Tres Marías, where Clara uncovers her husband's dark past and realizes her fate is bound to Pancha García and her descendants.

Clara recovers from her husband's violence, thanks to the love and care of her astral sisters, Luisa, Nora, and Marta Mora. With them, she transforms the big house on the corner, following the advice of spirits to shelter the needy, artists, and seekers of spirituality. Meanwhile, Blanca survives Pedro's absence, embarking on a journey into the unknown.