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Kane's corruption sweep threatens his political hold over the City Council. His mental symptoms begin to spiral out of control - Kane can no longer tell what is a hallucination and what is reality.
Kane attempts to clean house and deep-sixes longtime political cronies, while at home, Meredith and Emma want no part of a family reunion with him.
Kane's moves with the housing project escalate tensions from unrest to rioting and looting. As Chicago burns, Kane secretly seeks treatment at an alternative clinic, where his past haunts him.
This season, Kane ferociously beats back the physical symptoms of his illness with high doses of medication. But this comes at a cost -- experiencing heightened psychological manifestations of the disease. Without his longtime advisors Stone and Kitty, Kane is also forced to reconfigure his inner circle. Surrounded by strangers and without much time left, he acts quickly to protect and repair his legacy by cutting out the cancers within the political machine. But as corrupt heads roll and his list of enemies grows, Kane's virtuous actions begin to erode the very foundation of power he's worked a lifetime to build. In order to maintain it, Kane must govern as he always has - ruthlessly.