The incredible "upside-down man" goes to hospital for the first time since he was born. Can a life-threatening operation save this girl from her own face? The modern-day Elephant Man faces a medical test that could mean life or death. Will there be a diagnosis for the cyclist with one of the world's most mysterious illnesses? And will a second-round of surgery give the triplets with a brain-crushing skull syndrome a normal childhood?

It's a race against time for the 14 year old with an extraordinary growth on her neck; the fighting spirit that drives the lady with one of the world's rarest diseases; 4 year old conjoined twins face dangerous surgery; the woman with possibly the biggest hands in the world; and the girl who faced vicious bullying because of her skin.