Jools welcomes global superstar, The Voice judge and legendary singer Sir Tom Jones into the studio to discuss his musical journey, loves and influences, as illustrated by classic clips from the show. Together, they perform a track from Sir Tom's forthcoming forty-first studio album, Surrounded by Time, which reimagines a diverse set of songs of personal importance to the artist throughout his illustrious career.

Continuing the theme of unique performances in interesting locations, there is a performance from the restored Alexandra Palace Theatre in north London by Mercury prize-winning, genre-bending rockers Wolf Alice. The four-piece won the prize back in 2018 for their second album, Visions of a Life, and have been recently teasing their return with cryptic messages on their social media.

Also on the show and making his UK TV debut is the winner of the BBC Sound of 2021, British-Gambian rising star Pa Salieu, arguably the UK's hottest new rapper. Born in Slough, he grew up in the Gambia, and upon his return at the age of eight moved to Coventry. The city gave its name to his first mixtape, Send Them to Coventry, which was released in November and considers his Gambian heritage (and love of Gambian folk music), life in the Hillfields suburb, where he spent his formative years, and the trauma that he has encountered. It is just over a year since he released his breakthrough single Frontline. Pa Salieu is joined by Brit and Grammy-nominated singer Mahalia to perform their radio smash Energy.

Jools chats to actor, comedian and music lover Lenny Henry, who chooses and discusses his favourite performances from the archive. This special Later... falls on the same night as Comic Relief 2021, so as well as mining our vaults, Lenny shares a few of his favourite musical moments from the fundraising show across the years.

Meanwhile, two artists make their debut on the show. First up is Enny, a rapper and singer from Thamesmead in south east London. After releasing her first music just under a year ago, she immediately caught the attention of Jorja Smith, who made Enny the first signing to her label FAMM. Fast-forward to the end of the 2020 and Peng Black Girls, Enny's celebration of Black British women, catapulted her into the critics' ones to watch lists.

Second up is Leeds-London collective Nubiyan Twist with a unique performance of their latest single If I Know, featuring Ghanaian multi-instrumentalist and singer K.O.G and recorded at the home of the now-iconic east London jazz night Church of Sound. The track comes from the band's recently released third album Freedom Fables, a record that pays homage to traditional jazz and Afrobeat whilst embracing genres from hip-hop to garage, dub and everything in between.