Ghost Adventures becomes the first team to investigate the Castaneda Hotel in New Mexico. They later gain access to another haunted hotel, the Plaza Hotel, where an aggressive spirit is said to be targeting women.

The team investigates Grand Canyon Caverns in Peach Springs, AZ, formerly a sacred Indian burial site. The guys dodge mysterious rocks thrown at them during the night's lockdown, and Zak has an eerie, one-on-one encounter.