In this two-hour Halloween event, the Ghost Adventure crew travels across Texas on a personal Route 666. First they investigate the De Soto Hotel and Concordia Cemetery, both known for Satan worship. Then they head to Goatman's Bridge where a demon has attacked three women.

The Ghost Adventures crew investigates St. Anne's Retreat, where in 1997 a group of teenagers, drawn to the property for its legends of dead nuns and hellhounds, were held hostage and terrorized by three armed security guards.