Haunted by her experiences in Mexico, Nikki Alexander is struggling to come to terms with life back home.

Whilst on leave she seeks out fellow pathologist Sally Vaughan (Emma Fielding) for support. However, a few days later and troubled by the failure of Sally to return her calls, Nikki heads to her house only to find that it has become a crime scene and Sally is nowhere to be found.

Nikki and Jack deal with their feelings post Mexico in very different ways.

Jack is boxing with his sparring partner, DCI Naomi Silva when he is called to a crime scene.

While Nikki is busy examining the body of a young woman Karen Sawyers, Jack is surprised to find the SIO on the case is Naomi Silva.

The first prime suspect, Karen's husband Pete, is found covered in blood and clearly suffering. The forensic evidence leads the team to a cosmetic clinic, where a pregnant Karen had been receiving various treatments seemingly free of charge.

Nikki and Silva soon become frustrated when Simon Laing, the CEO of Hamilton Ashe hospital, blocks their access to Karen's medical records. However, when a second body is found and all evidence leads back to Hamilton Ashe, Laing is forced to help the team.

Meanwhile, when Thomas's daughter Rosie unexpectedly turns up at the Lyell, Thomas has to deal with a more complex role... being a father.