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As the Lyell team focus their investigation, they bring peril upon themselves. With the world they hold dear teetering on a knife edge, they confront their threats to preserve the credibility of DNA.
The death of an investigative journalist throws the spotlight onto Sam Ryan. Nikki begins to realise that the implications of her discoveries will challenge the principles of forensic science.
Seventeen years after leaving the Lyell, Sam Ryan returns asking for the team's help after a political assassination. The shooting of the Health Secretary pulls Lyell into a world of duplicity, intrigue, and betrayal.