Wo Fat is suspected of being behind the theft of a mobile ICBM device, and McGarrett with other top officials must stop him selling it off to the highest bidder.

A doctor tracking venereal disease is murdered, and Five-O must track the series of encounters to find out who is a carrier. Their investigation is made doubly important by the murder of a young woman who is close to a upcoming politician. He seems a likely suspect but McGarrett suspects a deeper plot.