Christina races to save a woman and her child in the wake of a car accident. But in a bizarre turn of events, the two victims develop a sudden paralysis seemingly unrelated to their accident injuries. Meanwhile, a cancer patient takes a surprising turn for the better; Kelly gets lost in the labyrinthine hospital; and a conniving Camille pushes to attend a class trip.

It's frenetic pandemonium at the hospital when another Richmond emergency room shuts down, forcing Christina and crew to care for an onrush of extra patients. One patient turns out to be Camille's school friend, who appears to have a drug problem. And a reporter plans to pen a revealing piece on the ER, with Ray serving as the inside source.