A mother (Jennifer Morrison) goes on the run with her young daughter after a grisly murder. The team must reassess their strategy for capturing her, however, when doubts arise about the woman's mental state.

While pursuing a fugitive who is using explosives as part of his revenge plan, Annie is injured and must turn to bounty hunter Ben Crowley (Eddie Cibrian) for help. With Annie on the shelf Jimmy must step up and lead the team, which puts Daisy's tactical experience to work in an effort to bring down the criminal, while Luke is forced to take a more pivotal part in the investigation.