Isane and Yachiru are treating the wounded Kensei and Rojuro when they are attacked by Gwenael, a Quincy who not only possesses the ability to disappear physically but can also erase his existence from his opponents' memories. Fortunately, Yachiru is able to rely on her natural instinct and reflexes in each of her "first battles" with the enemy. Getting the upper hand, Yachiru goes on the offensive by releasing her Zanpakuto, much to the surprise of Isane, who has never seen Yachiru's Shikai and its abilities. But just as Yachiru is backing Gwenael into a corner, a new enemy enters the scene.

Ichigo and the Soul Reapers try to stop Yhwach upon learning that his real target lies within the Royal Palace. However, their efforts are thwarted by Uryu, who stands in Ichigo's way in order to allow Yhwach safe passage to the Royal Palace. Although he knew their positions as Soul Reaper and Quincy would someday put them at odds with each other, Ichigo is still shocked by Uryu's unexpected betrayal. Still processing the situation with Orihime and Chad, who have just arrived from Hueco Mundo, Ichigo begins to remember the days he and Uryu fought side by side. Realizing what matters most, Ichigo makes the decision to take action. Meanwhile, Rukia and Renji face Bazz-B while Ikkaku and Yumichika take on Giselle. Cornered by the Soul Reapers, Giselle calls out for help.