When one of the profilers in the FBI's L.A.-based Violent Crimes Unit (VCU) is brutally murdered by a serial killer they've been tracking, rookie FBI Agent Rebecca Locke is recruited to join the team and help find the madman despite her lack of field experience. Unbeknownst to Rebecca, famed Supervisory Special Agent Vigil "WEB" Webster has personally selected her to join his rogue division - not for her impressive profiling skills, but because of a secret she's keeping. Web knows that Rebecca was abducted and held captive as a child, and the traumatic experience has afforded her unique insight into the mindset of villain and victim alike.

When a spate of murders targeting future serial killers start piling up, the VCU team find themselves matched against a cunning profiler who executes these would-be killers in the same way they would have killed their victims.