New Jump Street recruit Officer McCann is assigned to get close to a mentally handicapped youth in order to find out who murdered his partner in a buddy system which paired him and other mentally handicapped kids with troubled youths. Meanwhile, Hoffs and Penhall try to find out more about McCann's background.

When there's an outbreak of Ecstasy in a high school, Hoffs and McCann are sent to investigate. And it seems the school has a zero tolerance and has all the students take drug tests. When Hoffs takes the test, she comes up positive and is pulled out and is grilled by I.A. Mac decides that the student who spearheads the anti-drug campaign at the school is a person of interest.