A local talk radio host wants the sheriff's help in getting a TV show for him and his on-air partner, his wife. When Lucas says no, the host, Mel Kirby, finds a way to blackmail him through Ben. But Mel will pay the price for that. Caleb, meanwhile, gets an idea from Ms. Holt on how to reach Merlyn, who seems to be trapped somewhere in hell.

A plague hits Trinity, and Dr. Crower becomes infected and starts going wild, ranting about repentance. Gail succumbs to her passions with Sheriff Buck, and he's only too happy to oblige. A new doctor shows up in town from the CDC to deal with the plague, Dr. Billy Peale.