In the series pilot, social opposites Sam and Brooke are paired as lab partners, to the delight of Carmen, who sees it as a chance for Sam to help her get on the cheerleading squad. Meanwhile, Brooke and Nicole plan the first party of the school year and star quarterback Josh tries out for the school play.

Brooke and Sam are forced into dinner plans together with their parents; Sam's cheerleading expose ignites a war; Josh must choose between a football game or the school musical.