When her father Ludo ends up in hospital after a serious hunting accident, Isabelle returns to the Netherlands with her son Art, after having lived in America for years. Ludo asks Isabelle to take over the role of CEO in the family business, Rombauts Pharmaceuticals. This displeases her brother Julien, who has been working for the company for years and has big plans for the company in China. The statements that Isabelle makes in her new role at a talk show table are not appreciated by everyone. In the meantime, Art gets to know Lola. He is immediately impressed by her.

Lola is still missing, Art is desperate. While Julien is still being held against his will in China, Isabelle tries to keep various impatient investors on board. She is once again thrown back on her talent for improvisation. During an important presentation by Isabelle, unexpected help arrives from a mysterious guest of Julien. A journalist stumbles upon more and more things that Rombauts Pharmaceuticals probably does not want to be public. Art is completely disoriented by Lola's disappearance and gets into psychological trouble. Isabelle's mother Riekje comes to the rescue.