C.D.I. explores the chilling story of Angelina Rodríguez, who poisoned her husband, José Francisco "Frank" Rodríguez, after several failed attempts. The episode will also examine suspicions regarding her possible involvement in her daughter's death. 

C.D.I. will examine the Menéndez case, one of the most controversial trials of the 1990s. The trial of the Menéndez brothers for the murder of their parents in 1989 captured worldwide attention, sparking intense debate over family violence, abuse, and self-defense.