As Grace's ties to Chicago's Southside mob intensify, Constantine sends her to meet slain mob boss Paul Moretti's former rival, Donte Amato, who's suffering from an undiagnosed life-threatening condition. Meanwhile, romance at Roosevelt Medical Center pulses when Grace collaborates on a heart-wrenching case with Dr. Robinson involving a young bride experiencing severe mood swings.

Dr. Grace Devlin must save the life of an old friend injured in a pub-crawl accident, while tasked by Constantine with delivering the child of a pregnant call girl. Meanwhile, Franco has to track down a young woman whose whereabouts are crucial to his boss.