Zack gets teamed up with Screech to work on a science project at school. However, he soon discovers that Screech is rather depressed about not having a girlfriend and can't concentrate on getting their project done. As a result, Zack takes some drastic measures in finding Screech a date.

Mrs. Simpson accidentally throws her back out in class one day, resulting in Mr. Belding bringing in a substitute English teacher. When the girls in the class see how handsome Mr. Crane is, Zack and the rest of the guys in class start plotting to find a way to get the girls to notice them again.