Idealistic young Dr. Lily Brenner, along with fellow doctors Mina Minard and Tommy Fuller, arrive in "la ciudad de las estrellas" (the city of stars), a tiny town in the South American jungle which has one understaffed, under-stocked medical clinic. All of these young doctors are running away from personal demons, but they aren't the only ones with emotional baggage. They're introduced to the legendary and enigmatic Ben Keeton, who was the youngest Chief of Surgery at UCLA but who walked away from it all to found the clinic. Together with his right-hand doctor, Otis Cole, the mysterious Dr. Ryan Clark and local doctor, Zita Alvarez, he'll teach the newcomers how to save lives in the most challenging environment they've ever worked in -- while taking them on adventures of a lifetime.

The city is buzzing with the annual festival, but when a live wire electrocutes a young man and causes a citywide blackout, Mina and Otis fight for his life. Meanwhile a dangerous mudslide leaves a young pregnant couple in peril and the doctors scrambling to save them both.