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A ruthless assassin, Winston Smiles, is on the trail of Dixe Cousins because of vital evidence that she has against his employer. Brisco and Bowler come to her aid, and the trail leads to a nunnery where Dixie hid the evidence.
Brisco returns to his hometown to help an old friend of the family, the town sheriff, deal with a villianous cattle baron. He also renews a relationship with the sheriff's daughter and his previous girlfriend.
A series of mysterious robberies and the apparent murder of a bank manager implicate Brisco, who has a price put on his head. A female bounty hunter, Crystal Hawks, is the most persistent who captures Brisco several times (after he escapes several times).