When marshal Brisco County Sr. is gunned down by John Bly and his gang of outlaws, his son, bounty hunter Brisco County Jr., comes back from the East to gain revenge on the killers.

The Swill brothers (Will, Bill, Gil, and Phil) steal an experimental Army tank. Brisco is injured while pursuing them, and his ally Professor Wickwire takes him to a town populated entirely by women who have decided to move out on their own. The Swills arrive in town and go on a rampage, only to be thwarted by Brisco, Lord Bowler, the Professor, and the women.