Season Two picks up three months after the shocking arrest and incarceration of Empire Entertainment head LUCIOUS LYON (Terrence Howard). Still in federal lockup, Lucious is trying to run Empire from inside, while a headline-grabbing state prosecutor hangs her political ambitions on bringing him down - no matter what it takes. Meanwhile, Cookie stages a star-studded #FreeLucious concert in his support, while scheming with Andre, Hakeem, Anika and the business savvy Mimi Whiteman (guest star Marisa Tomei) to finalize the hostile takeover of Empire.

Cookie and Anika secretly work together behind Lucious' back to pull off a surprise performance that catches the eye of Pitbull (guest-starring as himself). Meanwhile, Lucious tracks down Frank Gathers' daughter, Young Ma (guest star Bre-Z Murray), to try to convince her to sign with him at Empire, while Hakeem is hard at work on his girl group, Ménage a Trois. Also, Andre and Rhonda hope their baby-on-the-way will be the key that unlocks Lucious' cold heart and opens the door for Andre to return to the Empire fold.