On 6 February 1996, Birgenair Flight 301 is scheduled to fly from Puerto Plata to Frankfurt. On takeoff, the captain finds that his airspeed indicator (ASI) is not reading properly, though the co-pilot's ASI is showing the correct speed; the aircraft subsequently crashes in the Atlantic Ocean. The pilots became confused and believed that both ASIs were malfunctioning, leading to loss of control of the aircraft. All 13 crew members and 176 passengers died. The cause of the disaster was believed to be a wasp that built a nest in one of the aircraft's pitot tubes, which was incorrectly left uncovered during the aircraft's extended stay at Puerto Plata airport.

On 29 September 2006, Gol Transportes Aéreos Flight 1907 and a brand new Embraer Legacy business jet (registered N600XL) on its delivery flight collide in mid-air over the Amazon rainforest. The Boeing 737 commercial flight crashes into the Amazon, but the Legacy manages to make a safe landing at an airbase. All 154 people on the Gol jet die. Air traffic controllers had cleared both aircraft to fly at the same altitude in opposite directions, and the transponder of the Legacy had either failed or had been switched off, making both aircraft's traffic collision avoidance systems useless in preventing the collision.