On 1 September 1983, during the Cold War, Korean Air Lines Flight 007 was shot down after violating Soviet airspace. The crew did not switch the autopilot from heading to INS mode following take off which caused the aircraft to deviate from its assigned flight path.

On 20 January 1992, Air Inter Flight 148 crashed into the Vosges Mountains while circling to land at Strasbourg Airport killing 87 people. An error made in programing the autopilot of the Airbus A-320, combined with a sudden wind change, caused the plane to descend more rapidly than expected.