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John accidentally receives two plane tickets to Chicago when he agrees to speak at a conference, so he takes Reggie with him. Meanwhile, Bob takes over as cook at the diner in Reggie's absence.
Reggie goes out with an old flame who is building a hospital in the area. Meanwhile, John fumes over his former research partner's patent for anti-wrinkle cream.
John isn't too pleased when a friend of a friend looks him up, but he changes his tune when he sees her and he realizes that she accepts him just as he is.