Captain Buck Rogers awakens in the year 2491 after 500 years in cryogenic suspension only to be captured by forces from the Draconian realm.

Buck, Wilma, Doctor Huer and Doctor Theopolis investigate a rash of illness that has incapacitated thousands of New Chicagoans. Eventually, they discover the cause: poisoned food discs. That discovery leads them to the remote agricultural planet Vistula, where a sinister demagogue's plans for Earth unfold...