The repetitive passing-on of the same cold strain in Dilbert's office causes it to mutate and turns the coworkers into monsters. Rather than eliminate the virus, the company decides to start fresh by moving everyone to a new office, which Dilbert is tasked with designing in exchange for a new office.

Dilbert loses "the knack" for technology when he gets management DNA from accidentally drinking from the Boss's cup. His resulting missteps send the world back to the Dark Ages.