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Police headquarters is quarantined when a man in custody appears to have an unknown infectious virus.
A law student attempts to commit the perfect crime by killing a stranger, confessing to the murder and recanting the confession. Meanwhile, Nancy tries to figure out the identity of a dead girl found in an alley and Kendall tries to end her relationship with a married man.
While in L.A., Mannion unexpectedly meets up with Vanessa Cavanaugh and offers her a ride. Unfortunately, the pair find themselves stranded in a deserted part of town after their rental gets carjacked. Back in Washington, Deputy Mayor Lockhart asks Debreno to help her find a blackmailer who has a scandalous videotape that could destroy her career; Kendall is threatened by her ex-boyfriend; and the mayor offers Ella a job.