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Donatello devises a cure to make Master Splinter human again. Meanwhile, Shredder plans to open a gate to Dimension X.
The turtles deal with four mutant frogs who are now under Shredder's command and also deal with a group of anti-mutant enforcers.
A robot cop, Rex-1, helps April and the Turtles defeat an evil army of robot cops under the control of Shredder.