Sparks fly between John and a student nurse. A store owner shoots an armed robber and is filled with remorse, a dog delays the rescue of an unconscious woman, a man is bitten by a Black Widow spider, Dr. Early deals with a man suffering from delirium tremens, and a man is injured at a chemical plant and trapped on some pipes. Dr. Brackett and Dixie deal with a tough man suffering from chest pains. Dixie and Dr. Morton assume an unconscious hippie is on drugs.

John comments on how weird things were going to happen on his shift, and he is proven right as they have to rescue a parachutist stuck in a tree. Also on that weird Wednesday, an obese man collapses while jogging; after an 80-year-old woman sprains her ankle while dancing at her birthday party, the guests go to the hospital to resume the fun; a man cannot stop hiccuping; a boy tries to freeze himself to preserve his body; a female golfer is bitten by a rattlesnake; a prostitute brings her john in after he suffers a heart attack; and finally, Gage and DeSoto rescue a drunk driver, during which Gage is injured. A seaman in pain shows up at Rampart, but speaks no English.