John complains about drivers failing to yield to the squad when their lights are on, so he writes the Chief who employs a deputy to monitor driver behavior. A college quarterback suffers from muscle cramps affecting his back which sidelines him from a big weekend game, Roy and John teach a CPR class to a group of senior citizens, then learn that their former paramedic instructor has died from cardiac arrest. The firefighters rescue a boy stuck upside down in a tree, and assist people trapped in a large fire at a hotel, complicated by a cardiac victim on the third floor.

A professor working with the Secret Service is experiencing symptoms of schizophrenia, and Dr. Brackett resents the interference of the government agents in the professor's care, where the professor's wife talks to Dixie, whose husband was brought over to the hospital for a physical examination. (The professor proves to have had MAO inhibitors prescribed to treat depression that had stricken him, but his physician had neglected to give him or his household staff proper dietary instructions.) Roy has an admirer calling him everywhere, despite Johnny saying, to both Dixie and Dr. Early, his partner has no "charisma," and needles him relentlessly about it. Between the phone calls, the paramedics assist a plane crash victim, deliver a premature baby, and help prevent a suicidal man from jumping off a building under construction.