John gets jealous when Brice is on the news, then their "favorite paramedic" leads another paramedic meeting in his own parliamentary way. Later, their Squad has to rescue Brice from a fire. The firefighters rescue a man's daughter from under a backhoe–then the father goes into cardiac arrest. Drs. Brackett and Morton treat a boy who accidentally shot himself with a BB gun and required a tracheotomy.

In a plot derived from The Towering Inferno, a high-rise building fire sparked by a carelessly thrown cigarette brings a multi-alarm response from Station 110, assisted by Squad 51. The fire traps several employees, including an office manager (Linda Gray) and her assistant (Anne Lockhart), who is engaged to one of the Squad 110 paramedics. Dr. Brackett leads a triage team from Rampart in a nearby garage. The Coast Guard helicopter is brought in to evacuate the trapped individuals. Dixie and Dr. Early handle the influx of patients at Rampart; while Roy and Johnny extricate themselves from a broken elevator, they also have to rescue an injured firefighter captain from an elevator shaft.