Port Wenn goes on lockdown when a patient with fleas sparks fears of a plague outbreak and Martin must deal with the town gossip when it revolves around him and Louisa. Also, Aunt Sarah feels betrayed by Greg and George and Louisa has an epiphany.

As the furious people of Port Wenn discover the truth about their deal with their Norwegian sister city, Martin must toggle between the potential revelation of his blood phobia, a startling baby delivery and the arrival of his amorous ex. Also, Louisa receives some thought-provoking medical results and Al and Elaine must navigate their uncertain future.