Steve and Rudy go to check up on scientist, Cheryl Osborne, who was performing research on chimpanzees but who has ceased communications. When they arrive they find something has destroyed the lab, and Rudy is bitten by a rampaging chimpanzee. Rudy begins to turn psychotic and Steve must both stop him and find Osborne before it's too late.

With Jaime Sommers critically injured after being attacked by two Fembots, Steve Austin races to Dr. Franklin's secret hideout to find the kidnapped Oscar Goldman. Austin plans to rescue his friend and boss despite Oscar's own orders to kill him lest he spills state secrets.

This episode is the middle chapter of a trilogy, with the other two episodes aired as part of The Bionic Woman series. "Kill Oscar: Part 2" is usually syndicated as a Bionic Woman episode.