Munich, Germany, 1923. Two years have passed since Edward Elric was dragged from his own world to ours, leaving behind his country, his friends and his younger brother, Alphonse Elric. Stripped of his alchemical powers, all this time he has been researching rocketry together with Alphonse Heiderich, a young man very much resembling his own brother, hoping to one day find a way back home.

His efforts so far have proven fruitless, but when he hears that the Thule Society, an occult group strongly tied to the Nazi Party, discovered what could be a clue to the location of the legendary, mystical place called Shamballa, Edward's hopes are renewed. Meanwhile, in his own world, Alphonse Elric ventures deeper into the mysteries of alchemy in search for a way to reunite with his older brother.