2000: Susan Berman was the daughter of a famous Las Vegas mobster, Davey "The Jew" Berman, who was a partner with "Bugsy" Siegel in the Flamingo Hotel. Robert Durst's closest friend since they attended UCLA together, she had a mobster's mentality and matching code of ethics; people said she would do anything for a friend. Since Kathie Durst's disappearance two decades earlier, Robert Durst had been the subject of media and public scrutiny, and she had become his spokesperson to the media. Some say that Robert and Susan kept each other's secrets, and that if anyone knew what happened to Kathie, it would be Susan. When a random tip leads ambitious Westchester County District Attorney Jeanine Pirro to re-open the investigation into the disappearance of Kathie Durst, her investigators focus on Susan Berman, a witness the police had overlooked back in 1982.

Present Day: In the 33 years since Kathie Durst disappeared, no progress has been made in finding out what happened to her, or finding her body. Without answers, her family and friends continue to hunt for the truth.